Our group is using chemical knowledge and computational techniques to design and synthesize sugar mimics, based on known structural properties of bioactive oligosaccharides and of their protein complexes.
Our expertise includes:
– synthesis of biologically active compounds and glycomimetics
– computer- aided drug design of new biologically active compounds
– structure- and ligand-based design of receptor antagonists
Anna Bernardi received her PhD in Industrial Chemistry and the University of Milan in 1986. She worked for two years as a post-doc with Clark W. Still at Columbia University, before coming back to Milano. Here she spent her academic career, becoming a Full Professor of Organic Chemistry in 2005. Her research is focused on the design and synthesis of biologically active molecules, with special focus on glycomimetics.
Laura Belvisi graduated in Chemistry cum laude at the University of Milano in 1990 and received her PhD in Chemical Sciences from the same University in 1994. After a post-doctoral fellowship, she became Researcher of Organic Chemistry at the University of Milano in 1998 and an Associate Professor of Organic Chemistry in 2015. From 2001 to 2011 she was the scientific director of the Molecular Modeling Laboratory at the Interdipartimental Center for bio-molecular Studies and Industrial applications (CISI) of the University of Milano.
Her main research interests are focused on the application of a broad range of computational modelling techniques for the design and the study of structural and functional mimics of biomolecules, such as peptides and carbohydrates.
