Structure-based design and synthesis of novel inhibitors of GlcNAcylating protein OGT

Elena Loi

Elena Loi obtained her MSc in Medicinal Chemistry and Pharmaceutical Technology at Università degli Studi di Cagliari, Sardinia, Italy. During her studies, she spent an Erasmus semester at the University of Ljubljana, Slovenia, to work on her master thesis “Synthesis and biological activity of new DNA gyrase inhibitors based on 4,5,6,7-tetrahydrobenzo[1,2-d]thiazole-2,6-diamine scaffold”. She is currently pursuing her PhD under the supervision of Prof. Marko Anderluh at the University of Ljubljana and Prof. Roland Pieters at the University of Utrecht. Her research work focuses on the design and synthesis of novel inhibitors of GlcNAcylating protein OGT.


  1. Elena Maria Loi, Matjaž Weiss, Stane Pajk, Martina Gobec, Tihomir Tomašič, Roland J. Pieters, Marko Anderluh, Intracellular Hydrolysis of Small-Molecule O-Linked N-Acetylglucosamine Transferase Inhibitors Differs among Cells and Is Not Required for Its Inhibition. Molecules 202025, 3381. doi: 10.3390/molecules25153381.
  2. Matjaž Weiss, Elena Maria Loi, Maša Sterle, Cyril Balsollier, Tihomir Tomašič, Roland J. Pieters, Martina Gobec, Marko Anderluh, New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth. Frontiers in Chemistry 2021, 9, 666122. doi: 10.3389/fchem.2021.666122.