The research of our group has a main focus on the biochemical and structural studies of lectins from opportunistic pathogens of bacterial or fungal origin responsible of severe bronchopulmonary infections. They mediate recognition and adhesion to host glycoconjugates so they can be targeted for the development of glyco based molecules as new anti-infectives. Our goals are (i) to identify soluble lectins involved in the adhesion of the pathogen to host glycoconjugates (ii) to dissect the interactions of lectin-glycoconjugates at the atomic level (iii) to design glycocompounds and (iv) to evaluate the potential of glycocompounds by in vitro studies.
Our expertise includes
– molecular biology
– biophysical characterisation of lectin-carbohydrate interactions
– protein X-ray crystallography
– molecular modelling of protein and/or carbohydrates